THINK

Inclusiecriteria: U mag meedoen als

Main inclusion criteria are:
- Men or women ≥ 18 years old at the time of signing the ICF,
- Patient with a CRC, epithelial ovarian cell or fallopian tube carcinoma, urothelial carcinoma, TNBC, pancreatic cancer, AML/MDS or MM,
- Disease must be measurable according to the corresponding guidelines,
- Patient with an ECOG performance status 0 or 1, and AML patients with anemia resulting in an ECOG performance status of 2,
- Patient with adequate bone marrow reserve, hepatic and renal functions.
-Patient must have sufficient pulmonary functions with a Forced Expiratory Volume in the first second (FEV-1)/Forced Vital Capacity (FVC) ≥ 0.7 with FEV-1 ≥ 50% predicted

Exclusiecriteria: U mag niet meedoen als

Main exclusion criteria are:
- Patient with a tumor metastasis in the central nervous system,
- Patients who have received another cancer therapy within 2 weeks before the planned day for the apheresis (except hydroxyurea for AML patients),
- Patients who receive or are planned to receive any other investigational product within the 3 weeks before the planned day for the first NKR-2 administration (except hydroxyurea for AML patients),
- Patient is under systemic immunosuppressive drugs, unless specific cases authorized per protocol.
- Patients who have received other cell therapies,
- Patients who underwent major surgery within 4 weeks before the planned day for the first NKR-2 administration.
- Patient cannot present with history of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, idiopathic pneumonitis and/or active or acute exacerbation of chronic obstructive pulmonary disease (COPD).

• Cliniques Universitaires Saint-Luc
• Institut Jules Bordet
• UZ Gent